产品货号：
Z30832
中文名称：
IGFBP5抗体
英文名称：
Anti-IGFBP5 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IGFBP5 Antibody |
| 指标别名 | IBP 5;IBP5;IGF binding protein 5;IGFBP 5;IGFBP5 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,ELISA |
| 基因名称 | IGFBP5 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human IGFBP5 recombinant protein (Position:A60-E272).Human IGFBP5 shares 96.7% and 96.2% amino acid (aa) sequence identity with mouse and rat IGFBP5,respectively. |
| 实际分子量 | 31KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Insulin-like growth factor-binding protein 5 is a protein that in humans is encoded by the IGFBP5 gene.The expression of IGFBP5 by stable transfection and adenovirus-mediated infection is inhibitory to growth in 2 human breast cancer cell lines.IGFBP5 expression leads to G2/M cell cycle arrest and apoptosis.Stable expression of IGFBP5 in the breast cancer cell lines also inhibits the formation and growth of tumors following injection in athymic mice.It is concluded that IGFBP5 is a growth inhibitor and proapoptotic agent in breast cancer cells.Additionally,IGFBP-5 is expressed by fibroblasts,myoblasts and osteoblasts,making it the predominant IGFBP found in bone extracts.It has a strong affinity for hydroxyapatite,allowing it to bind to bone cells.When bound to extracellular matrix,IGFBP-5 is protected from proteolysis and potentiates IGF activity,but when it is soluble,IGFBP-5 is cleaved to a biologically inactive 21kDa fragment (1,2). |
| Uniprot ID | P24593 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 (ELISA)： 1:100～1000 |
相关搜索：IGFBP5抗体，IGFBP5多抗，Anti-IGFBP5 Antibody